Advancing P4 Medicine Through Innovations in Science
The Ohio State University Wexner Medical Center-2012 Johanna and Ralph Destefano Personalized Health Care Conference
The Ohio State University Medical Center The Ohio State University Medical Center
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Photo of Johanna S. DeStefano
Johanna S. DeStefano
Professor Emeritus, The Ohio State University
Healthcare Advocate

DeStefano is a professor emeritus of language, literature and culture at The Ohio State University. She was on the faculty of the College of Education and Human Ecology for 30 years and served as an associate dean of the college from 1993 to 1998, primarily for research and development. Her research and scholarly writing focused on language and literacy teaching and learning in school and adult learning settings. She has authored and coauthored several books and many articles during her academic career.

DeStefano graduated with her bachelor’s degree in 1961, also being inducted into Phi Beta Kappa that year. She earned her master’s degree in 1963, and her PhD in linguistics and language education in 1970, all from Stanford University. She came directly from Stanford to Ohio State and remained there for her entire career.

Currently, DeStefano is the managing director of Baltimore Wireless, a company that holds an FCC license for the E group of 2.5 gHz channels in Baltimore, which are currently being used in 3G and 4G cell phones. This company was founded by her late husband, Ralph V. DeStefano, who was a media entrepreneur. She is also a member of the Opera Columbus Board of Directors, on the Board of Directors of the Columbus Symphony Orchestra, and is a member of the Red Cross International’s Tiffany Circle. Additionally, she is a member of the Board of Visitors of the School of Communications and Theatre, Temple University, her late husband Ralph’s alma mater, and here at Ohio State University, a member of the College of Education and Human Ecology’s Capital Campaign Committee.

Dr. DeStefano became interested in Dr. Clay Marsh’s work due to her own pulmonary condition of asthma and several bouts of pneumonia. This interest was underscored by a family history of pulmonary disease, with her mother dying of pulmonary fibrosis, and her maternal grandfather of silicosis, as well as other relatives in Finland of tuberculosis during the Winter War with the USSR. DeStefano, living with these conditions and several others over a period of time, has become aware of the interconnectedness of physical systems and their uniqueness from person to person. This is the foundation of her interest in personalized health care and the Center for Personalized Health Care directed by Dr. Marsh.

Photo of Joan McGonigal
Jane McGonigal
Creative Director, Social Chocolate
Author of The New York Times best seller, Reality Is Broken

Jane McGonigal is a visionary game designer and futurist, and she is harnessing the power of the Internet games in new ways to help solve some of the biggest challenges facing our world today and tomorrow.

Imagine a world where every challenge is a quest — where the harder a task is, the more people want to do it. Where people take pleasure in failing and come back invigorated every time they fall. Where they communicate spontaneously with their collaborators to pool their knowledge towards shared solutions. It turns out that world already exists. And if you draw on its secrets, you can transform your business: that creative collaboration, that effortless grasp of new technology, that very 21st-century connectivity and that power to solve complex problems can all be yours. Your guide to that world is Jane McGonigal. And that world? It’s the world of...gamers. Gamers? In her engaging, forward-thinking book Reality is Broken, Jane McGonigal makes the case that the gamer spirit — an attitude of fun, dedicated, collective problem-solving — is our greatest asset as we face the social, economic, and environmental problems of the 21st century.

She argues that game designers are effectively happiness engineers, experts in making difficult tasks engaging, and that we should draw on their smarts as we frame the challenges of our time. Jane herself is a specialist in this field, a designer of alternate reality games, where a real-life activity is re-framed as a game. The activity could be as mundane as household chores or as epic as surviving peak oil or establishing local sustainable businesses, the subjects of two of Jane’s own games: whatever the challenge, we can face it more boldly if we bring to it a gameful state of mind. But as Jane explains, in her quirky, spirited way, all of this is more than just a question of re-framing. It’s about bringing back to contemporary life the kind of heroism, epic purpose, and communal striving that so many of us struggle to find in our lives. With Jane’s help, you can understand how to channel that drive to revitalize your company — and fill our world with epic wins.

Credentials and Honors

  • Creative Director, Social Chocolate
  • Director of Game Research and Development, Institute for the Future, a non-profit futures research group based in Palo Alto, California
  • The New York Times best selling author
  • PhD, game research, the University of California at Berkeley
  • Named by Oprah Winfrey as one of the twenty most inspiring women in the world, O Magazine, 2010.
  • Honored by Game Developer Magazine as one of the 50 people making the biggest impact in games
  • Featured by The New York Times featured her as one of 10 scientists with a the best vision for what’s coming next in 2011
  • Fast Company’s 100 Most Creative People in Business, 2009


Photo of Leroy Hood
Leroy Hood, MD PhD
President and Co-founder
Institute for Systems Biology
Seattle, Washington

Dr. Hood is a pioneer in the systems approach to biology and medicine. His research has focused on the study of molecular immunology, biotechnology and genomics. Dr. Hood’s professional career began at Caltech, where he and his colleagues developed the DNA gene sequencer and synthesizer and the protein synthesizer and sequencer––four instruments that paved the way for the successful mapping of the human genome. A pillar in the biotechnology field, Dr. Hood has played a role in founding more than fourteen biotechnology companies, including Amgen, Applied Biosystems, Darwin, The Accelerator and Integrated Diagnostics. He is a member of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. Of the 6,000+ scientists world-wide who belong to one or more of these academies, Dr. Hood is one of only fifteen people accepted to all three. He is also a member of the American Philosophical Society and a Fellow of the American Academy of Arts and Sciences. His work has been widely published, and he has coauthored numerous textbooks in biochemistry, immunology, molecular biology and genetics, as well as a popular book on the human genome project, The Code of Codes. He is the recipient of numerous awards, including the Lasker Award for Studies of Immune Diversity, the Kyoto Prize in advanced technology, the Heinz Award for pioneering work in Systems Biology, and most recently, the coveted NAE 2011 Fritz J. and Delores H. Russ Prize for automating DNA sequencing that revolutionized biomedicine and forensic science. In addition to having received 17 honorary degrees from prestigious universities in the US and abroad, Dr. Hood has published more than 700 peer reviewed articles and currently holds 36 patents.

Photo of Janice Kiecolt-Glaser
Janice Kiecolt-Glaser, Ph.D.
Distinguished University Professor
and S. Robert Davis Chair of Medicine
The Ohio State University College of Medicine

Professor Janice Kiecolt-Glaser holds the S. Robert Davis Chair of Medicine in The Ohio State University College of Medicine; she also holds the title of Distinguished University Professor. She is a member of the OSU Institute for Behavioral Medicine Research as well as Professor of Psychiatry and Psychology. Working in the area of psychoneuroimmunology (PNI), she has authored more than 200 articles, chapters, and books, most in collaboration with Dr. Ronald Glaser. Their studies have demonstrated important health consequences of stress, including slower wound healing and impaired vaccine responses; they have also shown that chronic stress substantially accelerates age-related changes in inflammation, linked to some cancers, cardiovascular disease, type II diabetes, osteoporosis, arthritis, and frailty and function decline. In addition, their programmatic work has focused on how personal relationships influence immune and endocrine function, and health. See for an overview of her research and copies of her publications.

Most notable among her honors is her membership in the Institute of Medicine of the National Academy of Sciences. A Fellow in the American Association for the Advancement of Science, as well as the American Psychological Association, she received the Award for Outstanding Contributions to Health Psychology from Division 38 twice. She is listed in the Institute for Scientific Information (among the world's most highly cited authors, a group comprising less than one half of one percent of all publishing researchers). She has served on the editorial boards of 10 journals. Her research has been supported by a series of grants from the National Institutes of Health, including a MERIT award.

Photo of Bruce S. McEwen
Bruce S. McEwen, Ph.D.
Alfred E. Mirsky Professor
and Head of the Harold and Margaret Milliken Hatch
Laboratory of Neuroendocrinology at The Rockefeller University

He is a member of the US National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences and a Fellow of the New York Academy of Sciences. He served as Dean of Graduate Studies from 1991-3 and as President of the Society for Neuroscience in 1997-98. As a neuroscientist and neuroendocrinologist, McEwen studies environmentally-regulated, variable gene expression in brain mediated by circulating steroid hormones and endogenous neurotransmitters in relation to brain sexual differentiation and the actions of sex, stress and thyroid hormones on the adult brain. His laboratory discovered adrenal steroid receptors in the hippocampus in 1968. His laboratory combines molecular, anatomical, pharmacological, physiological and behavioral methodologies and relates their findings to human clinical information. His current research focuses on stress effects on amygdala and prefrontal cortex as well as hippocampus, and his laboratory also investigates sex hormone effects and sex differences in these brain regions. In addition, he served on the MacArthur Foundation Research Network on Socioeconomic Status and Health, in which he helped to reformulate concepts and measurements related to stress and stress hormones in the context of human societies. This led to the concept of “allostatic load” that describes the wear and tear on the body and brain from chronic stress and related life style behaviors that lead to dysregulation of phyiological stress pathways that are normally protective. He is also a member of the National Council on the Developing Child which focuses on healthy brain development as a key to physical and mental health. He is the co-author of book with science writer Elizabeth Lasley for a lay audience called “The End of Stress as We Know It” published in 2002 by the Joseph Henry Press and the Dana Press and another book with science writer Harold M. Schmeck, Jr. called “The Hostage Brain” published in 1994 by The Rockefeller University Press.

Stress- and Allostasis-Induced Brain Plasticity by Bruce S. McEwen and Peter J. Gianaros

Protective and Damaging Effects of Stress Mediators by Bruce S. McEwen, Ph.D.

Photo of Ann Pendleton-Jullian
Ann Pendleton-Jullian, Ph.D.
Walter H. Kidd Professor
and former Director of the Knowlton School of Architecture
The Ohio State University

Ann Pendleton‐Jullian is an architect, writer, and educator of international standing whose work explores the interchange between architecture, landscape, culture, science, and technology. She is currently the Walter H. Kidd Professor and former Director of the Knowlton School of Architecture at Ohio State University. From 1993‐2007, she was a tenured professor of architecture at MIT and Associate Head of the Department for three of those years.

Believing that design has the power and the potential to take on the challenges of contemporary life within an emerging global culture, ApJ’s design practice ranges between commissioned work, speculative projects, teaching as research, authored books and papers, exhibitions, seminars, lectures, and forums in which she applies her design expertise to a wide range of complex problems and discussions around complex problems.

ApJ’s projects range in scale and scope from things to systems of action. Notable projects demonstrating this range are: a house for the astronomer Carl Sagan; an award winning prototypical bioclimatic house for Tenerife; a hotel in the remote Nahuel Huapi Park in Argentina; the Highlands Center for environmental arts and sciences on Cape Cod; an award winning competition entry for the New Congress Hall in Valparaiso, Chile; and the Asian University for Women in Bangladesh. Currently she is working on a project to create a seven village ecosystem for rural craft-based tourism based in Guizhou province, China and St Claire Commons, an integrated patient centered health care system and facility in rural Ohio, being done in collaboration with OSU.

Within ApJ’s  work, writing is a form of reflection and inquiry, ranging from the analytical and critical to the speculative and visionary. Highly cited publications include: The Road That Is Not a Road and the Open City, Ritoque, Chile (MIT Press ,1996); Design Education and Innovation Ecotones (2009); Games for Shanghai (CA Press Shanghai, 2008); and numerous papers and articles. She has most recently finished a manuscript Design Unbound, with co-author John Seely Brown, that presents a new tool set for design within and on complex systems endemic to the 21st century.

In addition to lecturing extensively nationally and internationally within academic and public settings, ApJ has been a TEDx speaker, an invited participant to Aspen Institute roundtables both in the US and abroad and is often involved with the Highlands Forums Group – a cross-disciplinary network of global leaders established in 1995 by the Secretary of Defense to examine questions of emerging interest. She has been invited to participate as a designer in many domains outside of architecture including educational innovation, patient centered health ecosystems, human and economic development in developing countries/regions, and issues of security and international diplomacy.

ApJ has a three year undergraduate major in astrophysics (no degree), a Bachelor of Architecture degree from Cornell University and a Masters of Architecture from Princeton University. She has taught at Princeton, Harvard, Cornell, MIT, Yale, Tongji University in Shanghai, the Catholic University of Santiago, Chile and is currently Professor at OSU and a Distinguished Visiting Professor at Georgetown University.

Photo of Dave Snowden
Dave Snowden
Founder and Chief Scientific Officer
of Cognitive Edge

Dave Snowden is the founder and chief scientific officer of Cognitive Edge. His work is international in nature and covers government and industry looking at complex issues relating to strategy, organisational decision making and decision making. He has pioneered a science based approach to organisations drawing on anthropology, neuroscience and complex adaptive systems theory. He is a popular and passionate keynote speaker on a range of subjects, and is well known for his pragmatic cynicism and iconoclastic style.

He holds visiting Chairs at the Universities of Pretoria and Hong Kong Polytechnic University as well as a visiting fellowship at the University of Warwick. He is a senior fellow at the Institute of Defense and Strategic Studies at Nanyang University and the Civil Service College in Singapore. His paper with Boone on Leadership was the cover article for the Harvard Business Review in November 2007 and also won the Academy of Management aware for the best practitioner paper in the same year. He has previously won a special award from the Academy for originality in his work on knowledge managment. He is a editorial board member of several academic and practitioner journals in the field of knowledge management and is an Editor in Chief of E:CO. In 2006 he was Director of the EPSRC (UK) research programme on emergence and in 2007 was appointed to an NSF (US) review panel on complexity science research.

He previously worked for IBM where he was a Director of the Institution for Knowledge Management and founded the Cynefin Centre for Organisational Complexity; during that period he was selected by IBM as one of six “on-demand” thinkers for a world wide advertising campaign. Prior to that he worked in a range of strategic and management roles in the service sector.

His company Cognitive Edge exists to integrate academic thinking with practice in organisations throughout the world and operates on a network model working with Academics, Government, Commercial Organisations, NGOs and Independent Consultants. He is also the main designer of the SenseMaker® software suite, originally developed in the field of counter terrorism and now being actively deployed in both Government and Industry to handle issues of impact measurement, customer/employee insight, narrative based knowledge management, strategic foresight and risk management.

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  2012 Office of Extended Education